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Article

A Staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling.

Journal of innate immunity - 1 Jan 2014

Askarian Fatemeh, van Sorge Nina M, Sangvik Maria, Beasley Federico C, Henriksen Jørn R, Sollid Johanna U E, van Strijp Jos A G, Nizet Victor, Johannessen Mona

Abstract excerpt

Signaling through Toll-like receptors (TLRs), crucial molecules in the induction of host defense responses, requires adaptor proteins that contain a Toll/interleukin-1 receptor (TIR) domain. The pathogen Staphylococcus aureus produces several innate immune-evasion molecules that interfere with the host's innate immune response. A database search analysis suggested the presence of a gene encoding a homologue of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

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Source

Open in PubMed Open full text

Identifiers

PMID: 24481289
DOI: 10.1159/000357618
PMCID: PMC4198549

Genes

TLR2
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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