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The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells

13 Jan 2014

Abstract excerpt

WNT signaling is involved in maintaining stem cells in an undifferentiated state; however, it is often unclear which WNTs and WNT receptors are mediating these activities. Here we examined the role of the WNT receptor FZD7 in maintaining human embryonic stem cells (hESCs) in an undifferentiated and pluripotent state. FZD7 expression is significantly elevated in undifferentiated cells relative to differentiated...

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PMID: 24474766
DOI: 10.1073/pnas.1323697111

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