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Article

A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism.

Nucleic acids research - 1 Apr 2014

Dy Ron L, Przybilski Rita, Semeijn Koen, Salmond George P C, Fineran Peter C

Abstract excerpt

Bacterial abortive infection (Abi) systems are 'altruistic' cell death systems that are activated by phage infection and limit viral replication, thereby providing protection to the bacterial population. Here, we have used a novel approach of screening Abi systems as a tool to identify and characterize toxin-antitoxin (TA)-acting Abi systems. We show that AbiE systems are encoded by bicistronic operons and...

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Identifiers

PMID: 24465005
DOI: 10.1093/nar/gkt1419
PMCID: PMC3985639

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Source receipt: pubmed, retrieved 7 Sept 2026.

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