Stratification and delineation of gastric cancer signaling by in vitro transcription factor activity profiling and integrative genomics.

Abstract excerpt

Integrative functional genomic approaches are helpful in delineating the complex dysregulations in cancers. In the present study, in vitro activity profiling of 45 signaling pathway driven transcription factors in eight gastric cancer cell lines and direct comparison with genome-wide profiles of gastric tumors were performed and the integration resulted in the identification of three categories of...

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