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FGFR2 amplification has prognostic significance in gastric cancer: results from a large international multicentre study

23 Jan 2014

Abstract excerpt

BACKGROUND: In preclinical gastric cancer (GC) models, FGFR2 amplification was associated with increased tumour cell proliferation and survival, and drugs targeting this pathway are now in clinical trials. METHODS: FGFR2 FISH was performed on 961 GCs from the United Kingdom, China and Korea, and the relationship with clinicopathological data and overlap with HER2 amplification were analysed. RESULTS: The...

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PMID: 24457912
DOI: 10.1038/bjc.2013.802

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