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Article

Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults.

Journal of exposure science & environmental epidemiology - 1 Nov 2014

Drescher Olivia, Dewailly Eric, Diorio Caroline, Ouellet Nathalie, Sidi Elhadji Anassour Laouan, Abdous Belkacem, Valera Beatriz, Ayotte Pierre

Abstract excerpt

There is growing evidence that cardiovascular health can be affected by exposure to methylmercury (MeHg), by a mechanism involving oxidative stress. Paraoxonase 1 (PON1) is a high-density lipoprotein-bound enzyme that hydrolyzes toxic oxidized lipids and protects against cardiovascular diseases. Evidence from in vitro studies indicates that MeHg can inhibit PON1 activity but little is known regarding this effect...

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Source

Identifiers

PMID: 24448003
DOI: 10.1038/jes.2013.96

Genes

PON1

Variants

rs705379
rs705379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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