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The role of the osteopontin–integrin αvβ3 interaction at implantation: functional analysis using three different in vitro models

17 Jan 2014

Abstract excerpt

STUDY QUESTION: Does the interaction between integrin and its ligand osteopontin (OPN) mediate embryonic attachment to endometrial epithelium at implantation? SUMMARY ANSWER: OPN of epithelial origin binds the receptor integrin αvβ3 at the maternal surface to support adhesion during the early stages of implantation. WHAT IS KNOWN ALREADY: Integrin αvβ3 and OPN are both present in the endometrial luminal...

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PMID: 24442579
DOI: 10.1093/humrep/det433

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