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Article

Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene.

The Journal of clinical endocrinology and metabolism - 1 Apr 2014

Settas Nikolaos, Dacou-Voutetakis Catherine, Karantza Maria, Kanaka-Gantenbein Christina, Chrousos George P, Voutetakis Antonis

Abstract excerpt

CONTEXT: Central precocious puberty (CPP), defined as the development of secondary sex characteristics prior to age 8 years in girls and 9 years in boys, results from the premature activation of the hypothalamic-pituitary-gonadal axis. Mutations in the imprinted gene MKRN3 have been recently implicated in familial cases of CPP. OBJECTIVE: The objective of the study was to uncover the genetic cause of CPP in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24438377
DOI: 10.1210/jc.2013-4084

Genes

MKRN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene.PMID 24438377Read ↗

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