Article
Glomerular cell cross-talk influences composition and assembly of extracellular matrix.
Journal of the American Society of Nephrology : JASN - 1 May 2014
Byron Adam, Randles Michael J, Humphries Jonathan D, Mironov Aleksandr, Hamidi Hellyeh, Harris Shelley, Mathieson Peter W, Saleem Moin A, Satchell Simon C, Zent Roy, Humphries Martin J, Lennon Rachel
Abstract excerpt
The glomerular basement membrane (GBM) is a specialized extracellular matrix (ECM) compartment within the glomerulus that contains tissue-restricted isoforms of collagen IV and laminin. It is integral to the capillary wall and therefore, functionally linked to glomerular filtration. Although the composition of the GBM has been investigated with global and candidate-based approaches, the relative contributions of...
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