Article
Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin.
PloS one - 1 Jan 2014
Campbell Caitlin, Grapov Dmitry, Fiehn Oliver, Chandler Carol J, Burnett Dustin J, Souza Elaine C, Casazza Gretchen A, Gustafson Mary B, Keim Nancy L, Newman John W, Hunter Gary R, Fernandez Jose R, Garvey W Timothy, Harper Mary-Ellen, Hoppel Charles L, Meissen John K, Take Kohei, Adams Sean H
Abstract excerpt
Novel plasma metabolite patterns reflective of improved metabolic health (insulin sensitivity, fitness, reduced body weight) were identified before and after a 14-17 wk weight loss and exercise intervention in sedentary, obese insulin-resistant women. To control for potential confounding effects of diet- or microbiome-derived molecules on the systemic metabolome, sampling was during a tightly-controlled feeding...
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