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Global Metabolite Profiling in Feces, Serum, and Urine Yields Insights into Energy Balance Phenotypes Induced by Diet-Driven Microbiome Remodeling.

The American journal of clinical nutrition - 1 Oct 2025

Igudesman Daria, Yu GongXin, Dutta Tumpa, Carnero Elvis A, Krajmalnik-Brown Rosa, Smith Steven R, Corbin Karen D

Abstract excerpt

BACKGROUND: Preclinical literature and behavioral human data suggest that diet profoundly impacts the human gut microbiome and energy absorption-a key determinant of energy balance. To determine whether these associations are causal, domiciled controlled feeding studies with precise measurements of dietary intake and energy balance are needed. Metabolomics can serve as a readout of microbiome function, helping to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40835099
DOI: 10.1016/j.ajcnut.2025.08.003
PMCID: PMC12459606

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