Article
[Outcomes of patients with small bowel carcinoma treated with appropriate chemotherapy selected on the basis of genetic analysis findings].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Nov 2013
Suzuki Okihide, Ishibashi Keiichiro, Imaizumi Hideko, Amano Kunihiko, Hatano Satoshi, Matsuzawa Takeaki, Ogita Tomohiko, Kuwabara Koki, Sobajima Jun, Ishiguro Toru, Higashi Morihiro, Fukuchi Minoru, Kumamoto Keisuke, Baba Hiroyuki, Kumagai Yoichi, Tsuji Yoshitaka, Tamaru Junichi, Mochiki Erito, Ishida Hideyuki
Abstract excerpt
Small bowel carcinoma is a rare tumor, for which a standardized chemotherapy regimen has not yet been established. Further, this tumor may belong to the group of Lynch syndrome-associated tumors, which are resistant to 5-fluorouracil (5-FU) -based chemotherapy. We investigated mismatch repair protein expression and K-ras gene mutation status in 8 patients with aggressive small bowel carcinoma and determined the...
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