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Article

HE4 (WFDC2) gene overexpression promotes ovarian tumor growth

6 Jan 2014

Abstract excerpt

Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian cancer tumorigenesis but little is known about the role the HE4 gene or the gene product plays. Here we show that elevated HE4 serum levels correlate with chemoresistance and decreased survival rates in EOC patients. HE4 overexpression promoted xenograft tumor growth and chemoresistance against cisplatin in an...

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Share to Endometriosis Research and Treatment
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Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24389815
DOI: 10.1038/srep03574

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