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Article

MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance

3 Jan 2014

Abstract excerpt

BACKGROUND: Development of resistance to androgen deprivation therapy (ADT) is a major obstacle for the management of advanced prostate cancer. Therapies with androgen receptor (AR) antagonists and androgen withdrawal initially regress tumors but development of compensatory mechanisms including AR bypass signaling leads to re-growth of tumors. MicroRNAs (miRNAs) are small regulatory RNAs that are involved in...

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PMID: 24387052
DOI: 10.1186/1476-4598-13-1

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