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Article

Low-anxiety rat phenotypes can be further reduced through genetic intervention.

PloS one - 1 Jan 2013

de Medeiros Gabriela Ferreira, Pereira Elayne, Granzotto Natalli, Ramos André

Abstract excerpt

BACKGROUND: A previous study using an intercross between the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) identified a locus on chromosome 4, named Anxrr16, influencing an experimental index of anxiety and showing a transgressive effect, with alleles from the LEW strain (more anxious) decreasing rather than increasing anxiety. OBJECTIVE: To confirm the location and isolate the effect...

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Share to Anxiety
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Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24386249
DOI: 10.1371/journal.pone.0083666
PMCID: PMC3875470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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