Article
OGT and OGA expression in postmenopausal skeletal muscle associates with hormone replacement therapy and muscle cross-sectional area.
Experimental gerontology - 1 Dec 2013
Toivonen Minna H M, Pöllänen Eija, Ahtiainen Maarit, Suominen Harri, Taaffe Dennis R, Cheng Sulin, Takala Timo, Kujala Urho M, Tammi Markku I, Sipilä Sarianna, Kovanen Vuokko
Abstract excerpt
Protein glycosylation via O-linked N-acetylglucosaminylation (O-GlcNAcylation) is an important post-translational regulatory mechanism mediated by O-GlcNAc transferase (OGT) and responsive to nutrients and stress. OGT attaches an O-GlcNAc moiety to proteins, while O-GlcNAcase (OGA) catalyzes O-GlcNAc removal. In skeletal muscle of experimental animals, prolonged increase in O-GlcNAcylation associates with age and...
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