Article
Molecular classification of colorectal carcinomas: the genotype-to-phenotype relation.
World journal of gastroenterology - 7 Dec 2013
Kaemmerer Elke, Klaus Christina, Jeon Min Kyung, Gassler Nikolaus
Abstract excerpt
Colorectal carcinomas (CRCs) are frequently found in industrialized countries and lead to a high incidence of malignancy-related mortality. Defined by histomorphological features, CRCs and their pre-invasive lesions are quite heterogeneous. The underlying molecular mechanisms include genomic instability, genomic mutation of tumor suppressor genes or oncogenes, epigenetic changes, and the microRNA network. The...
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