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Article

Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Lu Kuan-Ming, Evans Sylvia M, Hirano Shinji, Liu Fu-Chin

Abstract excerpt

Striatal projection neurons comprise two populations of striatonigral and striatopallidal neurons. These two neuronal populations play distinct roles in controlling movement-related functions in the basal ganglia circuits. An important issue is how striatal progenitors are developmentally specified into these two distinct neuronal populations. In the present study, we characterized the function of Islet-1 (Isl1),...

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Identifiers

PMID: 24351932
DOI: 10.1073/pnas.1319138111
PMCID: PMC3890800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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