Article
Observational cohort study of ventricular arrhythmia in adults with Marfan syndrome caused by FBN1 mutations.
PloS one - 1 Jan 2013
Aydin Ali, Adsay Baran A, Sheikhzadeh Sara, Keyser Britta, Rybczynski Meike, Sondermann Claudia, Detter Christian, Steven Daniel, Robinson Peter N, Berger Jürgen, Schmidtke Jörg, Blankenberg Stefan, Willems Stephan, von Kodolitsch Yskert, Hoffmann Boris A
Abstract excerpt
BACKGROUND: Marfan syndrome is associated with ventricular arrhythmia but risk factors including FBN1 mutation characteristics require elucidation. METHODS AND RESULTS: We performed an observational cohort study of 80 consecutive adults (30 men, 50 women aged 42±15 years) with Marfan syndrome caused by FBN1 mutations. We assessed ventricular arrhythmia on baseline ambulatory electrocardiography as >10 premature...
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