Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness.

Scientific reports - 18 Dec 2013

Sinclair Duncan, Fillman Stu G, Webster Maree J, Weickert Cynthia Shannon

Abstract excerpt

Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the extent of such abnormalities in the brain is not known. Using RNA-Seq and qPCR in two postmortem cohorts totalin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Intramolecular Oxidoreductases
Share to Prefrontal Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Glucocorticoid

Share to Schizophrenia

Share to Sequence Analysis, RNA

Share to Stress, Psychological

Share to Tacrolimus Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24345775
DOI: 10.1038/srep03539
PMCID: PMC3866598

Genes

BAG1
FKBP5
PTGES3
DNAJB1
HSPB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24345775-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness.PMID 24345775Read ↗

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model.Semantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Lower cortical <i>FKBP5</i> DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophreniaSemantic proximity Read ↗

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorderSemantic proximity Read ↗

FKBP5 polymorphisms induce differential glucocorticoid responsiveness in primary CNS cells - First insights from novel humanized mice.Semantic proximity Read ↗

Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophreniaSemantic proximity Read ↗

Associations of psychiatric disease and aging on <i>FKBP5</i> expression converge on cortical supragranular neuronsSemantic proximity Read ↗

The emerging role of the FKBP5 gene polymorphisms in vulnerability-stress model of schizophrenia: further evidence from a Serbian population.Semantic proximity Read ↗

Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 ExampleSemantic proximity Read ↗

Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling PathwaysSemantic proximity Read ↗

Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disordersSemantic proximity Read ↗

Transcriptomic analysis uncovers the shared and unique biological foundations acrossSchizophrenia, Bipolar and Major Depressive DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.