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Article

Cancer as a metabolic disease: implications for novel therapeutics.

Carcinogenesis - 1 Mar 2014

Seyfried Thomas N, Flores Roberto E, Poff Angela M, D'Agostino Dominic P

Abstract excerpt

Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to...

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Identifiers

PMID: 24343361
DOI: 10.1093/carcin/bgt480
PMCID: PMC3941741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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