Article
Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience.
Stem cells translational medicine - 1 Feb 2014
Götherström Cecilia, Westgren Magnus, Shaw S W Steven, Aström Eva, Biswas Arijit, Byers Peter H, Mattar Citra N Z, Graham Gail E, Taslimi Jahan, Ewald Uwe, Fisk Nicholas M, Yeoh Allen E J, Lin Ju-Li, Cheng Po-Jen, Choolani Mahesh, Le Blanc Katarina, Chan Jerry K Y
Abstract excerpt
Osteogenesis imperfecta (OI) can be recognized prenatally with ultrasound. Transplantation of mesenchymal stem cells (MSCs) has the potential to ameliorate skeletal damage. We report the clinical course of two patients with OI who received prenatal human fetal MSC (hfMSC) transplantation and postnatal boosting with same-donor MSCs. We have previously reported on prenatal transplantation for OI type III. This...
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