Article
Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica.
PloS one - 1 Jan 2013
Chihara Norio, Aranami Toshimasa, Oki Shinji, Matsuoka Takako, Nakamura Masakazu, Kishida Hitaru, Yokoyama Kazumasa, Kuroiwa Yoshiyuki, Hattori Nobutaka, Okamoto Tomoko, Murata Miho, Toda Tatsushi, Miyake Sachiko, Yamamura Takashi
Abstract excerpt
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of optic neuritis and myelitis. It is generally accepted that autoantibodies against aquaporin 4 water channel protein play a pathogenic role in neuromyelitis optica. We have recently reported that plasmablasts are increased in the peripheral blood of this autoimmune disease, and are capable of producing autoantibodies...
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