Article
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Science (New York, N.Y.) - 13 Dec 2013
Rohner Nicolas, Jarosz Dan F, Kowalko Johanna E, Yoshizawa Masato, Jeffery William R, Borowsky Richard L, Lindquist Susan, Tabin Clifford J
Abstract excerpt
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a...
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