Article
Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials.
Critical reviews in oncology/hematology - 1 May 2014
Pilotto Sara, Di Maio Massimo, Peretti Umberto, Kinspergher Stefania, Brunelli Matteo, Massari Francesco, Sperduti Isabella, Giannarelli Diana, De Marinis Filippo, Tortora Giampaolo, Bria Emilio
Abstract excerpt
PURPOSE: We performed a sensitivity and meta-regression analysis, cumulating all randomized trials exploring the benefit of afatinib, erlotinib and gefitinib versus chemotherapy in advanced EGFR mutant NSCLC, to investigate the potential role of additional clinico-pathological predictors of TKIs efficacy. RESULTS: With regard to progression-free survival (PFS), a significant interaction according to ethnicity...
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