Article
Biological and clinical features in predicting efficacy of epidermal growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis.
Anticancer research - 1 Jul 2009
Garassino Marina Chiara, Borgonovo Karen, Rossi Antonio, Mancuso Andrea, Martelli Olga, Tinazzi Angelo, Di Cosimo Serena, La Verde Nicla, Sburlati Paola, Bianchi Celso, Farina Gabriella, Torri Valter
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), developed for patients with advanced non-small cell lung cancer (NSCLC), give modest results similar to those with chemotherapy. There is evidence of a greater survival benefit from TKIs in patients with certain molecular and clinical features, but results are conflicting. To assess the role of these factors in predicting TKI...
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