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Article

Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival

10 Dec 2013

Abstract excerpt

BACKGROUND: Ovarian cancer is a lethal gynecological malignancy largely due to the lack of biomarkers for early detection and treatment options. Opioid binding protein/cell adhesion molecule-like gene (OPCML) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of OPCML induces oncogenic transformation of human ovarian surface epithelial cells. METHODS: This study investigated OPCML...

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PMID: 24327526
DOI: 10.1515/cclm-2013-0736

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