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Article

Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jul 2014

Basile B, Castelli M, Monteleone F, Nocentini U, Caltagirone C, Centonze D, Cercignani M, Bozzali M

Abstract excerpt

BACKGROUND: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks. OBJECTIVE: RS-fMRI was used to investigate changes in FC within two...

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PMID: 24326671
DOI: 10.1177/1352458513515082

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