Article
The missense of smell: functional variability in the human odorant receptor repertoire.
Nature neuroscience - 1 Jan 2014
Mainland Joel D, Keller Andreas, Li Yun R, Zhou Ting, Trimmer Casey, Snyder Lindsey L, Moberly Andrew H, Adipietro Kaylin A, Liu Wen Ling L, Zhuang Hanyi, Zhan Senmiao, Lee Somin S, Lin Abigail, Matsunami Hiroaki
Abstract excerpt
Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors and found that 63% of the odorant receptors we examined had polymorphisms that altered in vitro...
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