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Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

4 Nov 2018

Abstract excerpt

Targeted cancer therapy has become one of the high potential cancer treatments. Human topoisomerase II (hTopoII), which catalyzes the cleavage and rejoining of double-stranded DNA, is an important molecular target for the development of novel cancer therapeutics. In order to diversify the pharmacological activity of chalcones and to extend the scaffold of topoisomerase inhibitors, a series of chalcones was...

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PMID: 30394113
DOI: 10.1080/14756366.2018.1507029

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