Article
Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid premenopausal women.
Journal of physiology and biochemistry - 1 Mar 2014
Arrizabalaga María, Larrarte Eider, Margareto Javier, Maldonado-Martín Sara, Barrenechea Lurdes, Labayen Idoia
Abstract excerpt
Given that leptin, ghrelin and thyrotropin play a major role in the regulation of resting energy expenditure (REE) and that the FTO rs9939609 and the MC4R rs17782313 polymorphisms have been proposed to affect energy homeostasis, we hypothesized that both polymorphisms are associated with REE and that these relationships can be mediated by leptin, ghrelin and thyrotropin in obesity. Therefore, the present study...
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