Article
Acquired drug resistance conferred by a KRAS gene mutation following the administration of cetuximab: a case report.
BMC research notes - 5 Dec 2013
Osumi Hiroki, Matsusaka Satoshi, Shinozaki Eiji, Suenaga Mitsukuni, Mingyon Mun, Saiura Akio, Ueno Masashi, Mizunuma Nobuyuki, Yamaguchi Toshiharu
Abstract excerpt
BACKGROUND: Although a number of studies have reported acquired drug resistance due to administration of epidermal growth factor receptor antibody inhibitors, the underlying causes of this phenomenon remain unclear. CASE PRESENTATION: Here we report a case of a 75-year-old man with liver metastasis at 3 years after a successful transverse colectomy to treat KRAS wild-type colorectal cancer. While initial...
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