Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.

doi:10.1038/nature11156

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Article

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.

Nature - 28 Jun 2012

Misale Sandra, Yaeger Rona, Hobor Sebastijan, Scala Elisa, Janakiraman Manickam, Liska David, Valtorta Emanuele, Schiavo Roberta, Buscarino Michela, Siravegna Giulia, Bencardino Katia, Cercek Andrea, Chen Chin-Tung, Veronese Silvio, Zanon Carlo, Sartore-Bianchi Andrea, Gambacorta Marcello, Gallicchio Margherita, Vakiani Efsevia, Boscaro Valentina, Medico Enzo, Weiser Martin, Siena Salvatore, Di Nicolantonio Federica, Solit David, Bardelli Alberto

Abstract excerpt

A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. After an initial response, secondary resistance invariably ensues, thereby limiting the clinical...

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Identifiers

PMID: 22722830
DOI: 10.1038/nature11156
PMCID: PMC3927413

Genes

KRAS
EGFR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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