Article
Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer.
Journal of biomolecular techniques : JBT - 1 Dec 2013
Baldwin Don A, Sarnowski Christopher P, Reddy Sabrina A, Blair Ian A, Clapper Margie, Lazarus Philip, Li Mingyao, Muscat Joshua E, Penning Trevor M, Vachani Anil, Whitehead Alexander S
Abstract excerpt
A microarray (LungCaGxE), based on Illumina BeadChip technology, was developed for high-resolution genotyping of genes that are candidates for involvement in environmentally driven aspects of lung cancer oncogenesis and/or tumor growth. The iterative array design process illustrates techniques for managing large panels of candidate genes and optimizing marker selection, aided by a new bioinformatics pipeline...
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