Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease.

The American journal of clinical nutrition - 1 Feb 2014

Amir Shaghaghi Mandana, Bernstein Charles N, Serrano León Alejandra, El-Gabalawy Hani, Eck Peter

Abstract excerpt

BACKGROUND: Crohn disease (CD) and ulcerative colitis (UC) are 2 common inflammatory bowel diseases (IBDs) associated with intestinal inflammation and tissue damage. Oxidative stress is suggested to play a major role in the initiation and progression of IBD. Vitamin C (ascorbate, ascorbic acid) supplementation has reduced oxidative stress in persons with IBD. The role of ascorbate transporters in IBD remains to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ascorbic Acid
Share to Canada

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colitis, Ulcerative

Share to Crohn Disease

Share to Dietary Supplements

Share to Genetic Loci

Share to Logistic Models

Share to Oxidative Stress

Source

Identifiers

PMID: 24284447
DOI: 10.3945/ajcn.113.068015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease.PMID 24284447Read ↗

Associations of solute carrier family 23 member 1 (SLC23A1) rs6596473 genetic variant with serum vitamin C status and gut microbial profiles in healthy adults: A cross-sectional study.Semantic proximity Read ↗

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.Semantic proximity Read ↗

Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.Semantic proximity Read ↗

Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases.Semantic proximity Read ↗

The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.Semantic proximity Read ↗

Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland.Semantic proximity Read ↗

The role of Vitamin D level and related single nucleotide polymorphisms in Crohn's disease.Semantic proximity Read ↗

Single-nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian white cohort.Semantic proximity Read ↗

Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.Semantic proximity Read ↗

Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease.Semantic proximity Read ↗

Vitamin D binding protein gene polymorphisms in ulcerative colitis among those of Han Chinese ancestry: Pathogenetic, diagnostic and management implications.Semantic proximity Read ↗

A missense variant in SLC39A8 confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.