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Article

Diversity, differentiation, and linkage disequilibrium: prospects for association mapping in the malaria vector Anopheles arabiensis.

G3 (Bethesda, Md.) - 10 Jan 2014

Marsden Clare Diana, Lee Yoosook, Kreppel Katharina, Weakley Allison, Cornel Anthony, Ferguson Heather M, Eskin Eleazar, Lanzaro Gregory C

Abstract excerpt

Association mapping is a widely applied method for elucidating the genetic basis of phenotypic traits. However, factors such as linkage disequilibrium and levels of genetic diversity influence the power and resolution of this approach. Moreover, the presence of population subdivision among samples can result in spurious associations if not accounted for. As such, it is useful to have a detailed understanding of...

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PMID: 24281424
DOI: 10.1534/g3.113.008326
PMCID: PMC3887528

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Source receipt: pubmed, retrieved 7 Sept 2026.

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