Article
Identification of FkpA as a key quality control factor for the biogenesis of outer membrane proteins under heat shock conditions.
Journal of bacteriology - 1 Feb 2014
Ge Xi, Lyu Zhi-Xin, Liu Yang, Wang Rui, Zhao Xin Sheng, Fu Xinmiao, Chang Zengyi
Abstract excerpt
The outer membrane proteins (OMPs) of Gram-negative bacterial cells, as well as the mitochondrion and chloroplast organelles, possess unique and highly stable β-barrel structures. Biogenesis of OMPs in Escherichia coli involves such periplasmic chaperones as SurA and Skp. In this study, we found that the ΔsurA Δskp double-deletion strain of E. coli, although lethal and defective in the biogenesis of OMPs at the...
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