Article
Genomic approaches to problems in pituitary neoplasia.
Endocrine pathology - 1 Sept 2014
Asa Sylvia L, Ezzat Shereen
Abstract excerpt
The genetic mutations underlying familial syndromes that include pituitary tumors are rarely noted in the majority of sporadic adenohypophyseal adenomas. In contrast, epigenetic dysregulation is common, resulting in differential expression of cell cycle and apoptosis regulators, adhesion molecules, growth factors, and metabolic determinants of cell function. Here, we discuss the diagnostic and therapeutic...
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