Article
Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge.
Mediators of inflammation - 1 Jan 2013
Esteban Elisabeth, Ferrer Ricard, Alsina Laia, Artigas Antonio
Abstract excerpt
Severe sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells. Removal of endotoxin could be an effective adjunctive approach to the management of sepsis. Devices to adsorb endotoxin or...
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