Article
Fitness benefits of low infectivity in a spatially structured population of bacteriophages.
Proceedings. Biological sciences - 7 Jan 2014
Roychoudhury Pavitra, Shrestha Neelima, Wiss Valorie R, Krone Stephen M
Abstract excerpt
For a parasite evolving in a spatially structured environment, an evolutionarily advantageous strategy may be to reduce its transmission rate or infectivity. We demonstrate this empirically using bacteriophage (phage) from an evolution experiment where spatial structure was maintained over 550 phage generations on agar plates. We found that a single substitution in the major capsid protein led to slower...
Topics
- Biological Evolution
- Environment
- Escherichia coli
- Host-Pathogen Interactions
- Microviridae
- Models, Biological
- Mutation
- Phenotype