Article
A 5'-regulatory region and two coding region polymorphisms modulate promoter activity and gene expression of the growth suppressor gene ZBED6 in cattle.
PloS one - 1 Jan 2013
Huang Yong-Zhen, Li Ming-Xun, Wang Jing, Zhan Zhao-Yang, Sun Yu-Jia, Sun Jia-Jie, Li Cong-Jun, Lan Xian-Yong, Lei Chu-Zhao, Zhang Chun-Lei, Chen Hong
Abstract excerpt
Zinc finger, BED-type containing 6 (ZBED6) is an important transcription factor in placental mammals, affecting development, cell proliferation and growth. Polymorphisms in its promoter and coding regions are likely to impact ZBED6 transcription and growth traits. In this study, rapid amplification of 5' cDNA ends (5'-RACE) analysis revealed two transcription start sites (TSS) for the bovine ZBED6 starting within...
Topics
- Alleles
- Animals
- Base Sequence
- Binding Sites
- Cattle
- Computational Biology
- Gene Expression Regulation
- Haplotypes
- Insulin-Like Growth Factor II
- Molecular Sequence Data