A novel PAX7 10-bp indel variant modulates promoter activity, gene expression and contributes to different phenotypes of Chinese cattle.

doi:10.1038/s41598-018-20177-8

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Article

A novel PAX7 10-bp indel variant modulates promoter activity, gene expression and contributes to different phenotypes of Chinese cattle.

Scientific reports - 29 Jan 2018

Xu Yao, Shi Tao, Zhou Yang, Liu Mei, Klaus Sebastian, Lan Xianyong, Lei Chuzhao, Chen Hong

Abstract excerpt

Paired box 7 (PAX7) gene regulates the conversion of muscle satellite cells into myogenic cells and participates in multi-step processes in myogenesis. Expression levels of PAX7 are decisive for its regulatory function. Previous reports revealed that PAX7 were responsible for the developmental traits of muscle. The relationship of the PAX7 promoter variants and livestock phenotypic traits has not been fully...

Topics

Animals
Cattle
DNA-Binding Proteins
Gene Expression
Genotype
INDEL Mutation
PAX7 Transcription Factor
Phenotype
Promoter Regions, Genetic
Protein Binding

Source

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Identifiers

PMID: 29379079
DOI: 10.1038/s41598-018-20177-8
PMCID: PMC5789009

Genes

PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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