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Article

Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.

Anaerobe - 1 Aug 2021

Gonzales-Luna Anne J, Spinler Jennifer K, Oezguen Numan, Khan Md Abdul Wadud, Danhof Heather A, Endres Bradley T, Alam M Jahangir, Begum Khurshida, Lancaster Chris, Costa Gabriela Pd, Savidge Tor C, Hurdle Julian G, Britton Robert, Garey Kevin W

Abstract excerpt

BACKGROUND: Fecal microbiota transplantation (FMT) aims to cure Clostridioides difficile infection (CDI) through reestablishing a healthy microbiome and restoring colonization resistance. Although often effective after one infusion, patients with continued microbiome disruptions may require multiple FMTs. In this N-of-1 study, we use a systems biology approach to evaluate CDI in a patient receiving chronic...

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Identifiers

PMID: 34044101
DOI: 10.1016/j.anaerobe.2021.102387
PMCID: PMC8384661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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