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Evaluation of vitamin B12 effects on DNA damage induced by paclitaxel

11 Nov 2013

Abstract excerpt

Paclitaxel (PAC) is an anticancer drug that has been shown to generate free radicals leading to irreversible cell injury. Vitamin B12 has antioxidative properties and can protect DNA from free radicals. In this study, we examined the possible genotoxic effect of PAC on DNA as well as the possible protective effect of vitamin B12 on DNA damage induced by paclitaxel. Sister chromatid exchanges (SCEs), chromosomal...

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PMID: 24215581
DOI: 10.3109/01480545.2013.851686

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