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Cinacalcet Monotherapy in Neonatal Severe Hyperparathyroidism: A Case Study and Review

8 Nov 2013

Abstract excerpt

CONTEXT: Neonatal severe hyperparathyroidism (NSHPT) is a severe form of familial hypocalciuric hypercalcemia characterized by severe hypercalcemia and skeletal demineralization. In most cases, NSHPT is due to biallelic loss-of-function mutations in the CASR gene encoding the calcium-sensing receptor (CaSR), but some patients have heterozygous mutations. Conventional treatment consists of iv saline,...

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PMID: 24203066
DOI: 10.1210/jc.2013-2834

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