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Article

Impact of 2-deoxy-D-glucose on the target metabolome profile of a human endometrial cancer cell line

1 Jan 2013

Abstract excerpt

2-deoxy-D-glucose (2DG) has been clinically evaluated for its potential use as an anticancer drug. Although 2DG is generally thought to inhibit the glycolytic pathway through accumulation of 2-deoxy-D-glucose-6-phosphate (2DG6P), it may also interfere with various other biological processes. Here, to further understand the role of 2DG as an inhibitor of tumor progression, we assessed the metabolism of 2DG in a...

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PMID: 24190234
DOI: 10.2220/biomedres.34.221

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