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Article

MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer

1 Nov 2013

Abstract excerpt

Nemo-like kinase (NLK), an evolutionarily conserved MAP kinase-related kinase, has been reported to be involved in the development of hepatocellular carcinoma (HCC), but the underlying mechanisms leading to oncogenic NLK are poorly understood. A comprehensive microRNA (miRNA) profiling analysis on human HCC tissues identified four downregulated miRNAs that may target NLK. Ectopic expression of miRNA mimics...

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PMID: 24189458
DOI: 10.1016/j.canlet.2013.10.030

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