Article
A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.
Molecular medicine reports - 1 Jan 2014
Hu Xiaopeng, Yu Jie, Zhou Xiang, Li Zhaoming, Xia Yun, Luo Zhiyong, Wu Yaqun
Abstract excerpt
The Mycoplasma genus comprises a group of microbes that cause persistent infection in humans and its role in promoting tumor development has long been a concern. Although mixtures of components isolated from Mycoplasma have been shown to activate host Rho family small GTPases and Stat3, no individual factor with this activity has been reported. In the current study, a conserved small GTPase-like protein fragment...
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