Article
PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women.
Journal of clinical pathology - 1 Apr 2014
Agboola Ayodeji, Musa Adewale, Banjo Adekumbiola, Ayoade Babatunde, Deji-Agboola Mopelola, Nolan Christopher, Rakha Emad, Ellis Ian, Green Andrew
Abstract excerpt
AIM: Indigenous black women with breast cancer (BC) show a high frequency of triple negative breast cancer (TNBC) comprising ER-, PR- and HER2- phenotypes and BRCA1 deficiency together with a high mortality rate, prompting speculation that risk factors could be genetic and the molecular portrait of these tumours may be different to those of Western women. Protein inhibitor of activated signal transducer (PIAS) γ...
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