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Article

A molecular dynamics examination on mutation-induced catalase activity in coral allene oxide synthase.

The journal of physical chemistry. B - 27 Nov 2013

De Luna Phil, Bushnell Eric A C, Gauld James W

Abstract excerpt

Coral allene oxide synthase (cAOS) catalyzes the formation of allene oxides from fatty acid hydroperoxides. Interestingly, its active site differs from that of catalase by only a single residue yet is incapable of catalase activity. That is, it is unable to catalyze the decomposition of hydrogen peroxide to molecular oxygen and water. However, the single active-site mutation T66V allows cAOS to exhibit catalase...

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PMID: 24164352
DOI: 10.1021/jp408486n

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